Ladislav Vyklický

Palmitoylation controls NMDA receptor function and steroid sensitivity


Ladislav Vyklický, PhD

Professor of Normal and Pathological Physiology

Institute of Physiology CAS
Third Faculty of Medicine

Charles University Prague

Czech Republic 🇨🇿

Biography: Ladislav Vyklický is the Head of the Laboratory of Cellular Neurophysiology at the Institute of Physiology CAS and a Professor of Normal and Pathological Physiology at the Third Faculty of Medicine, Charles University Prague. He obtained his M.D. degree from Charles University in Prague in 1981 and his Ph.D. in physiology and pathophysiology from the Institute of Physiology, Czechoslovak Academy of Sciences. He conducted postdoctoral research as a Fogarty Visiting Fellow and Fogarty Visiting Scientist in the Laboratory of Developmental Neurobiology, NIH, Bethesda, Maryland, USA (with Mark L. Mayer). Additionally, he held a Visiting Scientist position at the Max-Planck Institute for Cell Physiology in Heidelberg, Germany (with Professor Bert Sakmann). He was awarded the Prize of the Czechoslovak Academy of Sciences (1991) and the International Research Scholar Award from the Howard Hughes Medical Institute (1995–1999). In 2015–2020 he served as a Deputy Director of the Institute of Physiology CAS.

Prof. Vyklický's current research interests include the investigation of the functional and pharmacological properties of N-methyl-D-aspartate (NMDA) receptors. An emphasis is placed on understanding the molecular, cellular, and behavioral aspects relevant to human missense and nonsense variants, which are studied in various models, including recombinant receptors and genetically modified mouse models. His group is also involved in studies on the modulation of NMDA receptors by neurosteroids.

Selected Publications